Diabetic heart shows preferential secretion of inner mitochondrial membrane proteins in the presence of mitochondrial oxidative stress

REGULATION OF GLYCEMIC CONTROL BY SECRETED MODULAR CALCIUM-BINDING PROTEIN 1

The major problem for type 2 diabetes patients is an inability to control their blood glucose levels, and high blood glucose levels cause th..

LIPID METABOLISM IN HEALTH AND DISEASE

Obesity is associated with type 2 diabetes, fatty liver disease, cardiovascular disease and cancer. These inter-related diseases reduce life..

UNDERSTANDING MEDIATORS OF METABOLIC DISEASE

This research proposal will identify changes in liver-secreted proteins during the development of fatty liver, and in the transition from fa..

DISCOVERY AND VALIDATION OF BIOMARKERS FOR NONALCOHOLIC STEATOHEPATITIS AND LIVER FIBROSIS

Up to 80% of obese individuals have non-alcoholic fatty liver disease. A form of this disease called non-alcoholic steatohepatitis, or NASH,..